Caldesmon by Immunohistochemistry
Also known as: CALDES IHC
Use
Caldesmon by Immunohistochemistry is an assay used to identify the presence and distribution of Caldesmon protein within tissue samples. It aids in the differentiation of smooth muscle tumors from other tumor types, due to the expression of caldesmon in smooth muscles. This assay is useful in distinguishing leiomyosarcoma from other sarcomas and can be crucial for accurate tumor classification and treatment planning.
Special Instructions
Not provided.
Limitations
The test was developed and its performance characteristics were determined by ARUP Laboratories but it has not been cleared or approved by the US Food and Drug Administration. As an LDT, it is conducted in a CLIA certified laboratory and intended solely for clinical purposes. Results should be interpreted in conjunction with other clinical and diagnostic information.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Caldesmon
Protein
LOINC Codes
- 94736-6 - Tissue block ID Spec
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
2 slides
Container
Tissue transport kit
Collection Instructions
Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen (cells must be prepared into a cellblock). Transport tissue block or 5 unstained (3- to 5-micron thick sections), positively charged slides.
Storage Instructions
Room temperature or refrigerated. Ship in cooled container during summer months.
Causes for Rejection
Specimens submitted with non-representative tissue type. Depleted specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |
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