Carbonic Anhydrase IX by IHC
Also known as: CAIX IHC
Use
This test is a technical stain-and-return immunohistochemistry procedure for Carbonic Anhydrase IX (CAIX). It is useful in distinguishing clear cell renal cell carcinoma from other subtypes, such as chromophobe carcinoma or oncocytoma.
Special Instructions
Not provided.
Limitations
Specimens must be formalin-fixed, paraffin-embedded; frozen specimens are unacceptable. Slides should not be oven-baked. Sections must be properly fixed and embedded to maintain antigenicity; non-representative or depleted tissue is unacceptable.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Carbonic Anhydrase IX
Protein
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen (cells must be prepared into a cellblock). Transport tissue block or 5 unstained (3- to 5‑micron thick) positively charged slides in tissue transport kit (ARUP supply #47808). Minimum: 2 slides. If sending precut slides, do not oven bake.
Storage Instructions
Room temperature (also acceptable: refrigerated). Ship in cooled container during summer months.
Causes for Rejection
Non-representative tissue type; depleted specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |
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