CD4 by Immunohistochemistry
Also known as: CD4 IHC
Use
CD4 by Immunohistochemistry is used to evaluate the presence and pattern of CD4 protein expression on tissues or cells. CD4 is a glycoprotein found predominantly on the surface of immune cells such as T-helper cells, monocytes, macrophages, and dendritic cells. This test aids in the characterization of various lymphoproliferative disorders and other pathological conditions characterized by abnormal immune cell populations. It is particularly useful in the diagnosis and monitoring of diseases such as lymphomas, where CD4 expression helps differentiate between different subtypes of T-cell lymphomas.
Special Instructions
Not provided.
Limitations
This test is performed as a stain and return (technical) service only. Interpretive analysis is not included in this service, and pathologists should be aware that results should be interpreted within the context of histological and clinical findings. Inappropriate specimen type or quality, non-representative tissue type, or depleted specimens will be considered unacceptable for analysis.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
CD4
Protein
LOINC Codes
- 47016-1 - CD4 Ag Tiss Ql ImStn
- 94736-6 - Tissue block ID Spec
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
2 slides
Container
Tissue transport kit
Collection Instructions
Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen. If sending precut slides, do not oven bake.
Storage Instructions
Protect paraffin block and/or slides from excessive heat. Ship in cooled container during summer months.
Causes for Rejection
Depleted specimens. Specimens submitted with non-representative tissue type.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant