Chlamydia Antibody Differentiation (Lymphogranuloma Venereum) by Microimmunofluorescence
Also known as: LYMPH VEN
Use
The Chlamydia Antibody Differentiation (Lymphogranuloma Venereum) by Microimmunofluorescence test is used to detect and differentiate antibodies against different Chlamydia species, including C. trachomatis, C. pneumoniae, and C. psittaci. It is particularly useful for identifying Lymphogranuloma venereum (LGV) caused by C. trachomatis serovars L1, L2, and L3. Detection of specific IgM, IgG, and IgA antibodies helps to determine the nature of the infection, be it recent or past. Due to cross-reactivity among Chlamydia species, results should be interpreted alongside clinical findings.
Special Instructions
Not provided.
Limitations
The microimmunofluorescence methodology may show cross-reactivity among different Chlamydia species, particularly with C. trachomatis (D-K) serovars. The presence of IgM antibodies often indicates recent infection, but chlamydial IgM is highly cross-reactive, leading to possible false positives across species. IgA antibodies can help identify the specific infecting species, especially in the presence of crossreactive IgG, but quantitative values should be interpreted cautiously. Additionally, this test has not been cleared or approved by the FDA and is performed under CLIA regulations.
New York Approved
Methodology
Immunoassay (Immunofluorescence)
Biomarkers
LOINC Codes
- 43355-7 - C trach D+E+F+G+H+I+J+K IgG Titr Ser IF
- 43356-5 - C trach D+E+F+G+H+I+J+K IgA Titr Ser IF
- 43357-3 - C trach D+E+F+G+H+I+J+K IgM Titr Ser IF
- 44005-7 - CT D and K IgA+IgG+IgM Ser-Imp
- 6913-8 - C pneum IgG Titr Ser IF
- 6912-0 - C pneum IgA Titr Ser IF
- 6914-6 - C pneum IgM Titr Ser IF
- 50612-1 - C pneum IgA+IgG+IgM Ser-Imp
- 6916-1 - C psittaci IgG Titr Ser IF
- 6915-3 - C psittaci IgA Titr Ser IF
- 6917-9 - C psittaci IgM Titr Ser IF
- 44081-8 - C psittaci IgA+IgG+IgM Ser-Imp
- 90362-5 - C trach L1 IgG Titr Ser IA
- 90361-7 - C trach L1 IgA Titr Ser IA
- 90363-3 - C trach L1 IgM Titr Ser IA
- 90365-8 - CT L1 Ab.IgG+IgA+IgM Intrp Ser IA-Imp
Result Turnaround Time
5-9 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.2 mL
Container
ARUP standard transport tube
Collection Instructions
Collect specimen in a plain red or serum separator tube (SST). Transfer serum to a transport tube for submission.
Storage Instructions
Refrigerated; also acceptable at room temperature or frozen.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week |
| Refrigerated | 2 weeks |
| Frozen | 1 month |
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