Chlamydia Antibody Differentiation (Lymphogranuloma Venereum) by Microimmunofluorescence
Also known as: LYMPH VEN
Use
The Chlamydia Antibody Differentiation (Lymphogranuloma Venereum) by Microimmunofluorescence test is used to detect and differentiate antibodies against different Chlamydia species, including C. trachomatis, C. pneumoniae, and C. psittaci. It is particularly useful for identifying Lymphogranuloma venereum (LGV) caused by C. trachomatis serovars L1, L2, and L3. Detection of specific IgM, IgG, and IgA antibodies helps to determine the nature of the infection, be it recent or past. Due to cross-reactivity among Chlamydia species, results should be interpreted alongside clinical findings.
Special Instructions
The test is not performed at ARUP Laboratories; specimens need to be sent to the performing laboratory separately if multiple tests are required. This test is approved for use in New York State.
Limitations
The microimmunofluorescence methodology may show cross-reactivity among different Chlamydia species, particularly with C. trachomatis (D-K) serovars. The presence of IgM antibodies often indicates recent infection, but chlamydial IgM is highly cross-reactive, leading to possible false positives across species. IgA antibodies can help identify the specific infecting species, especially in the presence of crossreactive IgG, but quantitative values should be interpreted cautiously. Additionally, this test has not been cleared or approved by the FDA and is performed under CLIA regulations.
New York Approved
Methodology
Immunoassay (Immunofluorescence)
Biomarkers
LOINC Codes
- 43355-7
- 43356-5
- 43357-3
- 44005-7
- 6913-8
- 6912-0
- 6914-6
- 50612-1
- 6916-1
- 6915-3
- 6917-9
- 44081-8
- 90362-5
- 90361-7
- 90363-3
- 90365-8
Result Turnaround Time
5-9 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.2 mL
Container
ARUP standard transport tube
Collection Instructions
Collect specimen in a plain red or serum separator tube (SST). Transfer serum to a transport tube for submission.
Storage Instructions
Refrigerated; also acceptable at room temperature or frozen.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week |
| Refrigerated | 2 weeks |
| Frozen | 1 month |