Chromatin Antibody, IgG
Also known as: CHROMATIN
Use
The presence of anti-chromatin antibodies is associated with systemic lupus erythematosus (SLE) and drug-induced lupus (DIL). These antibodies may be predictive of lupus nephritis, particularly when antibody levels are high. The test measures the level of chromatin antibodies, aiding in the diagnosis of these conditions.
Special Instructions
Test performed on Serum separator tube. Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP standard transport tube (minimum 0.3 mL). Store and transport refrigerated to maintain stability. Unacceptable specimens include urine, plasma, contaminated, heat-inactivated, severely hemolyzed, icteric, or lipemic specimens.
Limitations
This test specifically measures chromatin antibodies, which are indicative of SLE or DIL, but may not detect all forms of lupus or other autoimmune conditions. Other tests and clinical factors must be considered for a comprehensive diagnosis.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 32580-3
- 32580-3
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection. Transfer to an ARUP standard transport tube.
Storage Instructions
Refrigerated.
Causes for Rejection
Urine or plasma. Contaminated, heat-inactivated, severely hemolyzed, icteric, or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year |