Chromosome Analysis, Bone Marrow
Also known as: CHR BM
Use
This test is used for the diagnosis, prognosis, and monitoring of hematopoietic neoplasms. It can help in identifying chromosomal abnormalities associated with conditions like myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). The detection of recurrent chromosomal abnormalities aids in disease classification and can provide prognostic information.
Special Instructions
Not provided.
Limitations
Analysis is based on culturing living cells, thus turnaround times are averages and can vary. Frozen or clotted specimens, or those with inadequate integrity for cell culture, may not be sufficient for analysis. Blood can be used if bone marrow is unavailable but may not yield the same diagnostic sensitivity. Results require correllation with clinical and other laboratory findings for accurate interpretation.
New York Approved
Methodology
Chromosomal / Cytogenetics (Karyotype)
Biomarkers
Unknown CNV
Copy Number Region
LOINC Codes
- 50659-2 - Chrom analy interphase Mar FISH-Imp
Result Turnaround Time
3-9 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
3 mL
Minimum Volume
0.5 mL
Container
Green (sodium heparin) tube
Collection Instructions
Collect nondiluted bone marrow aspirate in a heparinized syringe and transfer to a green (sodium heparin) tube.
Storage Instructions
Do not freeze or expose to extreme temperatures. Must be kept at room temperature.
Causes for Rejection
Frozen specimens, clotted specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 48 hours |
| Frozen | Unacceptable |
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