Chromosome Analysis, Products of Conception

Also known as: CHR POC

Clinical Use

Use

This test is performed to analyze chromosomes in products of conception, typically to investigate potential chromosomal abnormalities that may lead to miscarriage or stillbirth. It provides valuable information about genetic causes of pregnancy loss and is often used in cases of spontaneous abortion, missed abortion, or intrauterine fetal demise (IUFD). Genetic counseling based on the results can help guide future reproductive planning for individuals and families experiencing recurrent pregnancy loss.

Special Instructions

Not provided.

Limitations

The methodology used may not detect small chromosomal rearrangements or low-level mosaicism and cannot identify submicroscopic deletions or duplications effectively found using genomic microarray analysis. Results depend on the growth of cultured cells, which can be influenced by specimen quality and handling. Suboptimal samples might not yield conclusive results, with delays or compromised reporting outcomes.

Test Details

New York Approved

Methodology

Chromosomal / Cytogenetics (Giemsa Band)

Biomarkers

Chromosome Chromosome

Chromosome

G-Banding

Copy Number Alteration • Categorical (e.g., Positive / Negative / Indeterminate)

LOINC Codes

Order Codes

11526-1 - Pathology study
48819-7 - Karyotyp Tiss Fetus

Result Turnaround Time

14-28 days

Specimen

Tissue (Fresh)

Volume

Not provided

Minimum Volume

5 mg

Container

Sterile, screw-top container filled with tissue culture transport medium

Collection Instructions

Thaw media prior to tissue inoculation. Products of conception in a sterile, screw-top container filled with tissue culture transport medium. If cytogenetics tissue media is not available, collect in plain RPMI, Hanks solution, sterile saline, or ringers. If specimen size is too large for a normal collection tube, a larger sterile container can be used.