Chromosome Analysis, Products of Conception
Also known as: CHR POC
Use
This test is performed to analyze chromosomes in products of conception, typically to investigate potential chromosomal abnormalities that may lead to miscarriage or stillbirth. It provides valuable information about genetic causes of pregnancy loss and is often used in cases of spontaneous abortion, missed abortion, or intrauterine fetal demise (IUFD). Genetic counseling based on the results can help guide future reproductive planning for individuals and families experiencing recurrent pregnancy loss.
Special Instructions
Not provided.
Limitations
The methodology used may not detect small chromosomal rearrangements or low-level mosaicism and cannot identify submicroscopic deletions or duplications effectively found using genomic microarray analysis. Results depend on the growth of cultured cells, which can be influenced by specimen quality and handling. Suboptimal samples might not yield conclusive results, with delays or compromised reporting outcomes.
New York Approved
Methodology
Chromosomal / Cytogenetics (Giemsa Band)
Biomarkers
Chromosome Chromosome
Chromosome
LOINC Codes
- 11526-1 - Pathology study
- 48819-7 - Karyotyp Tiss Fetus
Result Turnaround Time
14-28 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Fresh)
Volume
Not provided
Minimum Volume
5 mg
Container
Sterile, screw-top container filled with tissue culture transport medium
Collection Instructions
Thaw media prior to tissue inoculation. Products of conception in a sterile, screw-top container filled with tissue culture transport medium. If cytogenetics tissue media is not available, collect in plain RPMI, Hanks solution, sterile saline, or ringers. If specimen size is too large for a normal collection tube, a larger sterile container can be used.
Causes for Rejection
Frozen specimens, intact fetus, specimens preserved in formalin, specimens consisting of maternal tissue only, autolyzed or contaminated specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 48 hours |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant