Products of Conception (POC) Profile

Casandra

Casandra Test Code LC52466Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 512200

Products of Conception (POC) Profile

Also known as: Placental Tissue, Chromosome Analysis and Histology, Products of Conception, Chromosome Analysis and Histology, Spontaneous Abortion, Chromosome Analysis and Histology

Clinical Use

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Use

This profile is used to rule out chromosome abnormalities as a cause of miscarriage.

Special Instructions

For cytogenetic analysis, a viable nonfixed specimen is required. Cytogenetics will handle viable specimens, and fixed specimens will be forwarded to histology. Additional charges may apply for histopathology procedures as assigned by the pathologist. Moreover, it is important to ensure that samples are not submitted in fixatives to avoid rejection due to incorrect specimen handling.

Limitations

The test has several limitations. Firstly, some products of conception samples may only contain maternal tissue, which could lead to inconclusive results regarding fetal chromosomal abnormalities. It is vital to ensure that an accurate sample is collected. Furthermore, sample viability is crucial for cytogenetic analysis as non-viable tissue could hinder the accurate assessment of chromosomal abnormalities. Additionally, shipping conditions must be controlled to avoid gross contamination and freezing of samples, as these will lead to rejection.

Test Details

Methodology

Culture-based

Biomarkers

Unknown chromosome

Chromosome

Karyotype • Copy Number Alteration • Categorical (e.g., Positive / Negative / Indeterminate)

LOINC Codes

Result Codes

62361-1
55199-4
62360-3
62358-7
62356-1
62357-9
48002-0
48672-0
11502-2
39111-0
92447-2
66746-9
56831-1
22636-5
18630-4
22637-3
22638-1
22635-7
22634-0
19139-5
62364-5
49560-6
76448-0
52797-8

Result Turnaround Time

10-15 days

Specimen

Tissue (Fresh)

Volume

20-50 mg

Minimum Volume

Not provided

Container

Sterile container with culture media (e.g., HAMS, RPMI), Ringer's lactate or Hank's balanced salt solution

Collection Instructions

Aseptically obtain a small piece of tissue with subepidermal layers. Best results are obtained from placental villi, which remain viable much longer than fetal tissue. If specimen is a product of conception, submit in a sterile tube with culture medium (HAMS, RPMI), Ringer's lactate or Hank's balanced salt solution.