Chromosome Analysis, Products of Conception, with Reflex to Genomic Microarray

Also known as: POC REFLEX

Clinical Use

Use

This test is useful to ensure the highest chance of obtaining meaningful results from fetal specimens. It involves chromosome analysis of products of conception to detect chromosomal abnormalities that may be responsible for miscarriage or other adverse fetal outcomes. The test reflexes to genomic microarray analysis if the chromosome analysis is normal, improving detection of submicroscopic deletions or duplications that may not be visible through standard cytogenetic methods.

Special Instructions

Not provided.

Limitations

The chromosome analysis involves culturing of living cells, which means that turnaround times are subject to variability. The standard cytogenetic methodology may not detect small rearrangements, low-level mosaicism, or submicroscopic deletions or duplications detectable by genomic microarray analysis. Additional cytogenetic testing by chromosome analysis or fluorescence in situ hybridization (FISH) may be needed for complete analysis of genomic imbalance.

Test Details

New York Approved

Methodology

Chromosomal / Cytogenetics (Giemsa Band)

Biomarkers

2 components

Chromosome Analysis • Giemsa BandGenomic Microarray • Giemsa Band

LOINC Codes

Order Codes

48819-7 - Karyotyp Tiss Fetus

Result Codes

11526-1 - Pathology study

Result Turnaround Time

14-36 days

Specimen

Tissue (Unknown)

Volume

Not provided

Minimum Volume

5mg

Container

sterile, screw-top container (e.g., ARUP supply #42710) filled with tissue culture transport medium

Collection Instructions

Thaw media prior to tissue inoculation. Transport products of conception in a sterile, screw-top container filled with tissue transport medium. If specimen size is too large for a normal collection tube, a larger sterile container can be used.