Cortisone by LC-MS/MS, Serum or Plasma
Also known as: CONE TMS
Use
The Cortisone by LC-MS/MS test measures the level of cortisone, a glucocorticoid hormone, in serum or plasma. Cortisone is involved in a variety of physiological processes including stress response, immune response modulation, inflammation reduction, and regulation of metabolism. The test is particularly useful for assessing adrenal gland function and diagnosing conditions like adrenal insufficiency, Addison's disease, and Cushing's syndrome. Monitoring cortisone levels can also aid in the evaluation of hypothalamic-pituitary-adrenal (HPA) axis disorders.
Special Instructions
Specimen should be collected between 8-10 a.m. to maintain consistent and reliable results due to diurnal variation in cortisone levels. Serum or plasma must be separated from cells as soon as possible or within 2 hours of collection to maintain sample integrity.
Limitations
Cortisone levels may be influenced by various factors including time of day, stress, and certain medications like glucocorticoids. The test does not differentiate between endogenous and exogenous sources of cortisone. Results should be interpreted in conjunction with clinical findings and other laboratory tests. Cross-reactivity with other steroids may occur, potentially impacting accuracy.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 14159-8
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Collect in a serum separator tube, lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin).
Patient Preparation
Specimen should be collected between 8-10 a.m.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | 1 week |
| Frozen | 6 months |