Dipeptidyl Aminopeptidase-Like Protein 6 (DPPX) Antibody, IgG by CBA-IFA With Reflex to Titer, Serum
Also known as: DPPX SER
Use
Aids in the diagnosis of limbic encephalitis. The test may be used to monitor treatment response in individuals who initially test positive for DPPX antibodies. The presence of DPPX antibodies is associated with symptoms such as hyperexcitability, pleocytosis, and frequent diarrhea. DPPX encephalitis may also be paraneoplastic, with hematologic malignancies reported in some patients.
Special Instructions
If DPPX antibody IgG is positive, then DPPX antibody IgG titer will be added. Additional charges apply.
Limitations
DPPX antibody is found in a subset of patients with autoimmune encephalitis and is often associated with prodromal gastrointestinal symptoms and unintentional weight loss. It may occur with or without an associated tumor. Decreasing antibody levels may be associated with therapeutic response. A negative test result does not rule out a diagnosis of autoimmune neurologic disease. Results should be interpreted in correlation with the patient's clinical history and other laboratory findings.
New York Approved
Methodology
Cell-based / Cytometry
Biomarkers
LOINC Codes
- 94676-4
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.2 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells within 2 hours of collection.
Causes for Rejection
Unacceptable conditions include CSF or plasma. Contaminated, hemolyzed, or severely lipemic specimens are not acceptable.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 30 days |