Paraneoplastic Antibody Expanded Evaluation with Reflex to Titer and LB, Serum
Also known as: Autoimmune Paraneoplastic Panel Reflex, Paraneoplastic Autoimmune Evaluation, PNS Expanded, Para Expanded Serum
Use
This assay aids in the diagnosis of paraneoplastic syndromes and associated malignancies, autoimmune encephalopathies, and other autoimmune neurological diseases by detecting a panel of antineuronal autoantibodies via multiple methods including tissue immunofluorescence (IFA), cell-based assay (CBA), radioimmunoassay, and reflex to line blot (LB) with titers where appropriate ([intellitestmanager.questdiagnostics.com](https://intellitestmanager.questdiagnostics.com/home/output/218380?utm_source=openai)).
Special Instructions
Panel always performs CBAs for cell surface autoantibodies (e.g., NMDA, AMPAR, GABA‑B receptor, LGI1, CASPR2) regardless of IFA screening result to increase sensitivity ([questdiagnostics.com](https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/faq292?utm_source=openai)).
Limitations
Not provided.
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
Result Turnaround Time
3-14 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
Not provided
Minimum Volume
Not provided
Other tests from different labs that may be relevant