Envoplakin Antibody, IgG by ELISA

Casandra

Casandra Test Code AR07607Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 3016533CPT Code 83516

Envoplakin Antibody, IgG by ELISA

Also known as: ENVO IGG

Clinical Use

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Use

Envoplakin Antibody, IgG by ELISA is used to aid in the diagnosis of paraneoplastic pemphigus (PNP), also known as paraneoplastic autoimmune multiorgan syndrome (PAMS), a rare disease associated with lymphoproliferative disorders and malignancies presenting with severe pemphigus-like clinical features and a high mortality rate. This test helps in assessing disease extent and activity, particularly in monitoring cases with increased IgG envoplakin antibody levels, making it useful in conjunction with other clinical indicators and histopathological assessments.

Special Instructions

This test should be distinguished from antibody testing for paraneoplastic neurologic syndromes. It is recommended to use this test in conjunction with Paraneoplastic Pemphigus Screening Antibodies by indirect immunofluorescence to aid diagnosis, with tissue biopsies and other epithelial antibody assessments for comprehensive evaluation. For optimal diagnosis and assessment, it may be ordered with panels that include other related antibodies such as the Immunobullous Disease Antibody Panel.

Limitations

An increased or normal IgG envoplakin antibody level by ELISA, as a stand-alone test, cannot completely confirm or rule out PNP/PAMS; it requires correlation with other tests and clinical features. The test has a high specificity of 96-99% and variably reported sensitivity of 55-86%. ELISA may be more sensitive than indirect immunofluorescence for low-level antibodies but might not detect the broad range of epithelial targets possible with immunofluorescence. False negatives could occur if only this ELISA is relied on without using complementary testing methods.

Test Details

New York Approved