Febrile Antibodies Identification Panel
Also known as: FBRL AB
Use
The Febrile Antibodies Identification Panel is used to confirm the presence of diseases associated with febrile antibody responses. It is particularly useful in identifying infections such as brucellosis, Rocky Mountain spotted fever, and typhus fever by detecting specific antibodies in the patient's serum. A seroconversion, or a significant rise in antibody titers between acute and convalescent samples, is considered strong evidence of a recent infection. This test is not recommended for initial testing but serves to confirm disease presence in individuals with compatible clinical histories and symptoms.
Special Instructions
For accurate results, it is crucial to separate the serum from cells as soon as possible or within two hours of collection. The convalescent specimens must be received within 30 days of the acute specimens for parallel testing. Mark specimens clearly as acute or convalescent for correct processing.
Limitations
The test may present cross-reactivity issues, notably between Brucella and Francisella tularensis antigens, which could lead to false-positive results if not interpreted in that context. Low levels of IgM antibodies may occasionally persist for more than 12 months after infection and could contribute to false positives, particularly in Rocky Mountain Spotted Fever diagnostics. As the antibodies' reactivity might include group reactivity, such as Typhus Fever group's Rickettsia prowazekii, interpretation of results should consider potential inclusivity of other organisms.
New York Approved
Methodology
Immunoassay (Other)
Biomarkers
LOINC Codes
- 19053-8
- 5307-4
- 5308-2
- 5324-9
- 5325-6
- 17562-0
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2.5 mL
Minimum Volume
1.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Collect serum using a Serum Separator Tube (SST). Remove serum from cells as soon as possible or within 2 hours of collection. Label specimens as acute or convalescent.
Storage Instructions
Transport refrigerated. Do not submit contaminated or heat-inactivated specimens.
Causes for Rejection
Contaminated or heat-inactivated specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year |