FISH, Interphase, CD138+ Cells
Also known as: FISHICD138
Use
This test is used for ordering individual or multiple FISH probes for patients with multiple myeloma. It identifies prognosis-specific genomic abnormalities by performing fluorescence in situ hybridization (FISH) on CD138+ sorted cells. The test is crucial for patients with multiple myeloma as it helps in assessing high-risk genomic features, which can correlate with prognosis and treatment strategies.
Special Instructions
Not provided.
Limitations
This test will not be performed unless the desired FISH probe and clinical diagnosis are provided. The sample prioritization for CD138+ cell sorting may impact chromosome analysis success. In cases where cell sorting does not yield enough cells, testing may be done on unsorted cells if available. Paraffin-embedded and clotted specimens are not acceptable. Ambient stability is 48 hours; refrigeration maintains stability for 48 hours, while freezing is not acceptable.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
CDKN2C, CKS1B
GeneDYNLT3-FGFR3 fusion
Fusion
LOINC Codes
- 57802-1 - Chrom analy interphase Bld/Mar FISH-Imp
- 11526-1 - Pathology study
Result Turnaround Time
3-9 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
3 mL
Minimum Volume
1 mL
Container
Green (sodium heparin) tube
Storage Instructions
Room temperature
Causes for Rejection
Paraffin-embedded specimens, clotted specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 48 hours |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant