Oncology FISH Analysis- Multiple Myeloma IgH Rearrangement FISH Panel
Use
Oncology FISH Analysis - Multiple Myeloma IgH Rearrangement FISH Panel is a Fluorescence In Situ Hybridization (FISH) test designed to identify the partner gene in IGH-mediated rearrangements. Chromosomal rearrangements between IGHG1 and CCND1, FGFR3, or MAF, as well as other genes, are associated with multiple myelomas. Results of this test must always be interpreted in the context of relevant clinical and pathological data and should not be used alone for a diagnosis of disease. The test is indicated for patients with a clinical or suspected diagnosis of multiple myeloma, for prognostic identification of anomalies in diagnosed patients, when cytogenetic testing was unsuccessful, and to track and monitor treatment/therapy response.
Special Instructions
When ordered alongside the Multiple Myeloma FISH Panel (code 8015), this test will only be activated if there is evidence of an IGH rearrangement. The expected turnaround time for test results is 3-4 days following the initial FISH analysis for multiple myeloma with identified rearrangements.
Limitations
This FISH assay only determines translocations involving the IGH, FGFR3, CCND1, and MAF genes. Translocations involving other partner genes cannot be determined from this analysis.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
3-4 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow (Fresh)
Volume
3-5 cc
Minimum Volume
2 cc
Container
Sodium Heparin Tube (Green-Top)
Collection Instructions
Draw bone marrow in a Sodium Heparin (green-top) tube(s) and send.
Storage Instructions
Ship at ambient temperature (18-25°C/64-77°F) in an insulated container by overnight courier.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
Other tests from different labs that may be relevant