Use

The FUS (16p11) Gene Rearrangement by FISH test is used to detect translocations involving the FUS gene. It is particularly useful for identifying low-grade fibromyxoid sarcoma (LGFMS) and distinguishing myxoid liposarcoma/round cell liposarcoma from other soft tissue tumors. A positive FUS rearrangement supports the diagnosis of LGFMS. The test is based on the performance during validation and is expected to detect 100 percent of FUS rearrangements in patients with FUS rearranged tumors, except for rare instances of cryptic rearrangements.