Genomic SNP Microarray, Products of Conception

Also known as: ARRAY POC

Clinical Use

Use

This test is used in the context of intrauterine fetal demise or stillbirth when further cytogenetic analysis is required. It's particularly relevant for pregnancy loss or termination in the presence of fetal anomalies, chromosomal abnormalities detected through conventional cytogenetic methods, multiple fetal losses of unknown etiology, or when products of conception specimens fail to grow in culture.

Special Instructions

Not provided.

Limitations

Certain genomic alterations may not be detected by this technology. These include CNVs below the resolution limit, sequence-level variants such as point mutations and indels, low-level mosaicism, balanced chromosomal rearrangements, and genomic imbalance in repetitive regions. Additional cytogenetic testing, such as chromosome analysis or FISH, is recommended for comprehensive evaluation. The test does not provide structural information of genomic imbalance and might miss some cases of tetraploidy.

Test Details

Methodology

Microarray

Biomarkers

Unknown biomarker

Other

Regions of Homozygosity

Other • Binary (Detected / Not Detected)

Unknown CNV

Copy Number Region

DNA Copy Number Changes

Copy Number Alteration • Categorical (e.g., Positive / Negative / Indeterminate)

LOINC Codes

Result Codes

96984-0 - Chrom analy POC Microarray

Result Turnaround Time

14-21 days

Specimen

Tissue (Fresh)

Volume

Not provided

Minimum Volume

5mg

Container

Sterile, screw-top container filled with tissue transport medium

Collection Instructions

Thaw media before tissue inoculation. Products of conception in a sterile container filled with culture transport medium. If no cytogenetics media is available, use plain RPMI, Hanks solution, sterile saline, or ringers. For autopsy, collect various tissue types such as facia lata, diaphragm, tendon, skin, etc.