Growth Hormone, 15 Minutes
Also known as: GH 15
Use
This test is used for the assessment of growth hormone (GH) levels to diagnose conditions such as growth hormone deficiency (GHD) in both pediatric and adult patients. In pediatric patients, very low peak GH concentrations on stimulation testing are consistent with severe GHD. In adults, the expected peak GH concentrations depend on the stimulation test performed, as described in the Endocrine Society guidelines. For suppression testing, healthy subjects should have GH concentrations of less than 1 ng/mL within 2 hours of ingestion of a 75 or 100 gram glucose dose, while patients with acromegaly fail to show normal suppression.
Special Instructions
This Growth Hormone assay is standardized to the Recombinant Second International Standard (IS): 98/574, and results read approximately 25 percent lower than with the previous standards (First IS: 80/505). Reference ranges have been modified according to the assay manufacturer.
Limitations
Thresholds distinguishing normal from partial GHD have not been well established. Inadequate response to two different provocative tests is required for diagnosis of GHD. Interpretation may vary based on the stimulation or suppression test performed, as specific guidelines and reference intervals apply.
FDA ApprovedNew York Approved
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 14142-4
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL per timed specimen
Minimum Volume
0.4 mL per timed specimen
Container
Plasma separator tube or serum separator tube
Collection Instructions
Collect one tube per timed specimen. Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer to individual ARUP Standard Transport Tubes.
Storage Instructions
Frozen. Also acceptable: Refrigerated.
Causes for Rejection
Tissue or urine. Grossly hemolyzed or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 1 week |
| Frozen | 2 months |