Histone Antibody, IgG
Also known as: AHA
Use
The Histone Antibody, IgG test is used for the evaluation of suspected drug-induced lupus. It is significant in differentiating this condition, as histone antibodies are present in 80-95% of drug-induced systemic lupus erythematosus (SLE) cases, compared to only 20-55% in idiopathic SLE and less than 20% in other connective tissue diseases. A negative result does not rule out drug-induced lupus.
Special Instructions
Not provided.
Limitations
While this test can detect the presence of histone antibodies, a negative result does not exclude the possibility of drug-induced lupus. Additionally, the presence of histone antibodies alone is not definitive for diagnosing SLE as they can also occur in other autoimmune conditions. The interpretive limits are categorical, based on units detected, and do not assess damage or predict disease progression.
FDA ApprovedNew York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
Histone Antibody, IgG
Protein
LOINC Codes
- 29996-6 - Histone IgG Ser IA-aCnc
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
Serum separator tube; transfer to ARUP Standard Transport Tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection.
Storage Instructions
Refrigerated.
Causes for Rejection
Plasma or urine; contaminated, grossly hemolyzed, icteric, or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year (avoid repeated freeze/thaw cycles) |
Other tests from different labs that may be relevant