Immunoglobulin G/Albumin Ratio, CSF
Also known as: IGG/ALB
Use
The Immunoglobulin G/Albumin Ratio in cerebrospinal fluid (CSF) is used to evaluate the integrity of the blood-CSF barrier and provides information regarding antibody production within the central nervous system. This test is crucial in the context of neuropathological conditions where the production of immunoglobulins might be altered, aiding in the assessment of diseases such as multiple sclerosis or other inflammatory conditions.
Special Instructions
It is important to collect CSF carefully to avoid contamination with blood. Refrigeration is required for transport to maintain the stability of the sample. Ensure to centrifuge and separate the sample to remove cellular material before transferring to the transport tube.
Limitations
The test may have limitations if the CSF sample is grossly bloody or hemolyzed, which can affect the accuracy of the results. It is also not applicable if there is no paired serum specimen to provide a comprehensive assessment of the IgG/albumin levels across compartments. Interpretation must be performed in conjunction with clinical findings and other laboratory results, as increased levels may not always indicate pathology.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Quantitative Immunoturbidimetry)
Biomarkers
LOINC Codes
- 1746-7
- 2464-6
- 2470-3
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Centrifuge and separate to remove cellular material before transferring.
Storage Instructions
Refrigerated
Causes for Rejection
Grossly bloody or hemolyzed specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | 1 month |
| Frozen | 6 months |