Insulin, Other

Also known as: INSULINOTH

Clinical Use

Use

This test is used to measure insulin levels in the blood. It provides valuable information for assessing insulin levels in patients, which can aid in the diagnosis and management of conditions related to insulin production and function, such as diabetes mellitus. The test measures the amount of insulin in the serum and reacts on a nearly equimolar basis with several insulin analogs: insulin aspart, insulin glargine, and insulin lispro, with insulin detemir showing approximately 50% cross-reactivity. Test reactivity with insulin glulisine is negligible (< 3 percent).

Special Instructions

Not provided.

Limitations

The test has not established a reference interval and exhibits various levels of cross-reactivity with insulin analogs. Users should note the specific reactivity: insulin aspart, insulin glargine, and insulin lispro react on a nearly equimolar basis, while insulin detemir shows about 50% cross-reactivity. Insulin glulisine shows negligible reactivity, which may impact the interpretation when these analogs are present. Furthermore, interpretations should consider the conversion factor of µIU/mL to pmol/L by multiplying by 6.0.

Test Details

FDA Approved

New York Approved

Methodology

Immunoassay (CLIA)

Biomarkers

Insulin

Analyte

Insulin Level

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Result Codes

20448-7 - Insulin SerPl-aCnc

Result Turnaround Time

1 day

Specimen

Serum

Volume

1 mL

Minimum Volume

0.4 mL

Container

ARUP Standard Transport Tube

Collection Instructions

Allow sample to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube.