IRF8 by Immunohistochemistry
Also known as: IRF8 IHC
Use
This immunohistochemical stain for IRF8 serves as a laboratory‑developed test (LDT) primarily used as a stain‑and‑return service; it enables detection of IRF8 expression in tissue specimens, useful in diagnostic contexts where understanding monocytic or dendritic cell lineage differentiation is relevant (e.g., hematopoietic malignancies), though explicit clinical use context is not detailed on this page.
Special Instructions
Not provided.
Limitations
Specimen limitations include submission of nonrepresentative tissue type, depleted specimens, or improperly processed tissue (non‑paraffin‑embedded or not on positively charged slides). Slides must not be oven baked if precut. Frozen specimens are unacceptable for transport; serum, blood, or other body fluids are unacceptable. Slides or blocks must be protected from excessive heat.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
IRF8
Protein
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen (cells must be prepared into a cell block). Transport tissue block or 2 unstained (3‑ to 5‑micron thick) positively charged slides in a tissue transport kit (ARUP supply #47808). Min: 2 slides. If sending precut slides, do not oven bake.
Storage Instructions
Room temperature or refrigerated; ship in cooled container during summer months.
Causes for Rejection
Nonrepresentative tissue type; depleted specimens; tissue or cells not processed and placed in a paraffin block; serum, blood, or other body fluids; tissue not mounted on positively charged slides.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant