Islet Cell Cytoplasmic Antibody, IgG
Also known as: ANTI-ISLET
Use
Islet cell antibodies (ICAs) are associated with type 1 diabetes (T1D), an autoimmune endocrine disorder. These antibodies can be present years before the onset of clinical symptoms, making them an essential marker for the diagnosis of autoimmune diabetes mellitus. The detection of these antibodies aids in establishing the autoimmune etiology in patients with previously diagnosed type 1 diabetes mellitus.
Special Instructions
For the determination of autoimmune diabetes mellitus (DM), it is recommended to perform at least two antibody tests. In most cases, combine the glutamic acid decarboxylase antibody test with another antibody test, such as the Islet Cell Cytoplasmic Antibody test.
Limitations
The test should not be used to distinguish type 1 diabetes mellitus from type 2 diabetes mellitus in most cases. Plasma and CSF samples, as well as hemolyzed or lipemic specimens, are not acceptable for this test. The test and performance characteristics were determined by ARUP Laboratories and have not been cleared or approved by the FDA, although it is performed in a CLIA-certified laboratory for clinical purposes.
New York Approved
Methodology
Immunoassay (Indirect Fluorescent Antibody (IFA))
Biomarkers
LOINC Codes
- 13927-9
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.50 mL
Container
Serum separator tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection. Transfer serum to an ARUP standard transport tube.
Storage Instructions
Refrigerated
Causes for Rejection
Plasma. CSF. Contaminated, hemolyzed, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month |