JC Virus Antibody by ELISA, Serum with Reflex to Inhibition Assay
Also known as: JCV AB
Use
This qualitative test detects antibodies to the John Cunningham (JC) virus. It is used to aid in risk stratification for the development of progressive multifocal leukoencephalopathy (PML) in individuals with multiple sclerosis or Crohn's disease who are receiving natalizumab therapy. Detection of antibodies can indicate exposure to the virus, which is a key factor in assessing the risk of PML.
Special Instructions
Not provided.
Limitations
The test is not performed at the ARUP laboratory, and separate specimens are necessary when multiple tests are ordered, requiring coordination with different testing facilities. The test results depend on accurate specimen collection and preservation to maintain stability, as room temperature stability lasts one week, refrigerated stability lasts two weeks, and frozen stability lasts three months.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
JCV Antibody
Protein
LOINC Codes
- 100977-8 - JC virus Ab Index SerPl IA-aCnc
- 70173-0 - JCPyV Ab SerPl Ql IA
Result Turnaround Time
6-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube
Collection Instructions
Collect in plain red or serum separator tube (SST). Lavender (K2EDTA) is also acceptable.
Storage Instructions
Frozen. Acceptable alternatives are room temperature or refrigerated.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week |
| Refrigerated | 2 weeks |
| Frozen | 3 months |
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