JC Virus by PCR
Also known as: JC VIRUS
Use
The test detects the presence of JC virus DNA which can indicate an active infection. This is particularly significant in immunocompromised patients where JC virus can cause progressive multifocal leukoencephalopathy (PML), a potentially fatal demyelinating disease. Detecting JC virus DNA in clinical specimens like CSF, plasma, serum, or urine can aid in diagnosing active JC virus infection, allowing for appropriate clinical management.
Special Instructions
New York state approval indicates high regulatory standards met for this test. Specimen source must be specified when submitting samples. Orderable as JC Virus PCR, JCV, John Cunningham Virus, JC polyomavirus, etc. Routine performance on Monday, Wednesday, and Friday ensures timely reporting, beneficial for patients undergoing immunosuppressive therapies where JC virus is active. Specimen submission should include clear labeling and adequate volume as per provided collection instructions.
Limitations
The test does not determine JC virus titers or quantify viral load. Detection is qualitative and may miss low levels of virus below assay detection limits or cases where PCR inhibitors are present. Negative results do not definitively exclude JC virus infection due to these potential technical limitations. Variability in specimen handling, storage, or sample quality can also impact results. It is critical to interpret results in conjunction with clinical findings and other laboratory tests for a comprehensive diagnosis.
New York Approved
Methodology
PCR-based (PCR)
Biomarkers
LOINC Codes
- 31208-2
- 42921-7
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
0.5 mL
Container
Lavender (EDTA), pink (K2EDTA) or serum separator tube
Collection Instructions
Separate serum or plasma from cells and transfer to a sterile container. Specify source.
Storage Instructions
Freeze the sample for transport.
Causes for Rejection
Heparinized specimens, tissues in optimal cutting temperature compound.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 8 hours |
| Refrigerated | 5 days |
| Frozen | 30 days |