Lead, Random Urine
Also known as: U LEADRAND
Use
This test is used to assess chronic lead exposure and monitor chelation therapy. Lead levels in random urine samples can indicate the degree of exposure to lead, especially in cases where blood lead levels are challenging to assess. Urinary excretion of lead increases following chelation therapy, which can be used as a therapeutic monitoring strategy.
Special Instructions
Dietary supplements, vitamins, minerals, and nonessential medications may introduce substances that interfere with the test. High concentrations of iodine may affect test results, hence collection should be avoided for at least 72 hours after exposure to iodinated or gadolinium-based contrast media. Patients with impaired kidney function should avoid urine collection for 14 days post-contrast exposure.
Limitations
Results may be affected by contamination during collection, specifically if non-trace element-free containers are used. Elevated results suspected to be due to contamination should be confirmed with a second specimen in certified trace element-free containers. Urinary lead excretion greater than 125 micrograms per 24 hours is generally associated with lead toxicity, but results should be interpreted along with clinical presentation and other tests for lead exposure, such as blood lead levels.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 0025062
- 0025065
- 35674-1
- 30931-0
- 13466-8
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
8 mL
Minimum Volume
1 mL
Container
ARUP Trace Element-Free Transport Tubes
Collection Instructions
Collect random urine. Avoid collection within 72 hours after administration of iodinated or gadolinium-based contrast media. Transfer 8 mL aliquot from a well-mixed collection to appropriate transport tubes.
Patient Preparation
Patients should discontinue nonessential supplements and medications. Avoid collection post-contrast media exposure for specified durations.
Causes for Rejection
Urine collected within 72 hours after administration of iodinated or gadolinium-based contrast media.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week |
| Refrigerated | 2 weeks |
| Frozen | 1 year |