Lymphocyte Subset Panel 5 - Total Lymphocyte Enumeration
Also known as: TIMMUNPAN
Use
The Lymphocyte Subset Panel 5 test plays a crucial role in evaluating individuals for primary immunodeficiencies, including severe combined immunodeficiency. It is also instrumental in monitoring immune reconstitution following transplantation. The test provides essential data by enumerating the percent and absolute cell counts of lymphocyte subsets, including CD4 helper T-cells, CD8 cytotoxic T-cells, B-cells expressing CD19, and natural killer cells. It is important for managing HIV-related conditions, with CD4 T-cell levels being used to inform decisions around prophylaxis and antiviral therapy initiation.
Special Instructions
Not provided.
Limitations
This test has been developed and its performance validated by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration and is offered from a CLIA-certified laboratory for clinical purposes. As with any test, understanding the limitations such as potential impacts of medication, sample handling, and stability constraints is critical for interpretation. It is also recommended to perform the test consistently within specified timeframes for comparison in longitudinal studies.
Methodology
Cell-based / Cytometry (Flow Cytometry)
Biomarkers
LOINC Codes
- 48767-8 - Annotation comment Imp
- 15195-1 - Cells.CD3-CD19+ # Bld
- 32519-1 - CD3-CD16+CD56+ Cells NFr Spec
- 20604-5 - CD3-CD16+CD56+ Cells # Spec
- 8122-4 - CD3 Cells # Bld
- 20599-7 - CD3 Cells NFr Spec
- 24467-3 - CD3+CD4+ Cells # Bld
- 14135-8 - CD3+CD8+ Cells # Bld
- 8123-2 - CD3+CD4+ Cells NFr Bld
- 32518-3 - CD3+CD8+ Cells NFr Spec
- 20593-0 - CD19 Cells NFr Spec
- 54218-3 - CD3+CD4+ Cells/CD3+CD8+ Cll Bld
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
4 mL
Minimum Volume
0.5 mL
Container
Lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin) Hemogard tubes
Storage Instructions
Transport at room temperature, avoid refrigerated or frozen conditions
Causes for Rejection
Clotted or hemolyzed specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | EDTA: Ambient: 72 hours, Heparin: Ambient: 48 hours |
| Refrigerated | Unacceptable |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant
