Ma2/Ta Antibody, IgG by Immunoblot, Serum
Also known as: MA2/TA SER
Use
Aids in the diagnosis of autoimmune cerebellar ataxia and encephalitis. The presence of Ma2/Ta antibodies may be associated with cerebellar ataxia, encephalitis, dementia, and brainstem encephalitis. Patients with Ma2/Ta antibody disease may have paraneoplastic conditions primarily associated with testicular cancer and adenocarcinoma. Utilization of immune checkpoint inhibitors is linked to an increased risk of anti-Ma2 paraneoplastic neurologic disease. Recommended testing in CSF alongside serum may enhance diagnostic yield.
Special Instructions
Interpret results in the context of the patient's clinical picture, as false positives may occur, and a negative result does not exclude the diagnosis of paraneoplastic neurologic disease.
Limitations
Test results may not definitively diagnose or exclude paraneoplastic neurologic disease. Results should be interpreted alongside clinical evaluations and other diagnostic findings. As with any laboratory test, false positives and negatives can occur, potentially influencing treatment decisions.
New York Approved
Methodology
Immunoassay (Immunoblot)
Biomarkers
LOINC Codes
- 82423-5
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.30 mL
Container
ARUP standard transport tube
Collection Instructions
Collect in Serum separator tube. Separate serum from cells ASAP or within 2 hours of collection.
Storage Instructions
Refrigerate after separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month
Causes for Rejection
Plasma. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month |