Metabotropic Glutamate Receptor 1 (mGluR1) Antibody, IgG by CBA-IFA With Reflex to Titer, Serum
Also known as: MGLUR1 SER
Use
This test aids in the diagnosis of cerebellar ataxia and limbic encephalitis. It can also be used to monitor treatment response in individuals who are antibody positive. The presence of mGluR1 antibodies may be associated with subacute cerebellar ataxia, dysgeusia, dysarthria, head titubation, and cognitive impairment. mGluR1 encephalitis may be paraneoplastic; hematologic malignancies are reported in a subset of patients.
Special Instructions
Test interpretation requires clinical correlation. If mGluR1 antibody IgG is positive, then mGluR1 antibody IgG titer will be added, leading to additional charges.
Limitations
A negative test result does not rule out a diagnosis of autoimmune cerebellar ataxia or limbic encephalitis. Interpretation of any antineural antibody test requires clinical correlation. The test was developed and its performance characteristics determined by ARUP Laboratories. It is intended for clinical purposes but has not been cleared or approved by the U.S. FDA.
New York Approved
Methodology
Immunoassay (Cell-based)
Biomarkers
LOINC Codes
- 93498-4
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.2 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate serum from cells within 2 hours of collection.
Storage Instructions
Refrigerated.
Causes for Rejection
CSF or plasma. Contaminated, grossly hemolyzed, icteric, or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month |