Motor and Sensory Neuropathy Evaluation with Immunofixation Electrophoresis and Reflex to Titer and Neuronal Immunoblot
Also known as: MSNCR
Use
This test aids in diagnosing combined motor/sensory neuropathy, particularly when a plasma cell dyscrasia or other malignancy is suspected. The evaluation includes detection of antibodies through several immunoassays, which are associated with various peripheral neuropathies. For example, anti-GM1 antibodies are linked with motor or sensorimotor neuropathies, while GD1b antibodies are related to sensory ataxic neuropathy syndrome.
Special Instructions
Not provided.
Limitations
The presence of ganglioside antibodies is not solely diagnostic and should be interpreted in conjunction with other clinical parameters. These tests are not FDA cleared or approved, but are performed in a CLIA certified laboratory. Factors such as contamination, heat-inactivation, and severe hemolysis can affect the test results.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 2862-1 - Albumin SerPl Elph-mCnc
- 2865-4 - Alpha1 Glob SerPl Elph-mCnc
- 2868-8 - Alpha2 Glob SerPl Elph-mCnc
- 2871-2 - B-Globulin SerPl Elph-mCnc
- 2874-6 - Gamma glob SerPl Elph-mCnc
- 2458-8 - IgA SerPl-mCnc
- 2465-3 - IgG SerPl-mCnc
- 2472-9 - IgM SerPl-mCnc
- 2885-2 - Prot SerPl-mCnc
- 25700-6 - Interpretation SerPl IFE-Imp
- 88723-2 - GM1 Asialo IgG+IgM Ser IA-aCnc
- 31500-2 - GM1 Gangl IgG+IgM Ser-aCnc
- 88724-0 - GD1a Gangl IgG+IgM Ser IA-aCnc
- 88730-7 - GD1b Gangl IgG+IgM Ser IA-aCnc
- 88729-9 - GQ1b Gangl IgG+IgM Ser IA-aCnc
- 31666-1 - SGPG IgM Ser-aCnc
- 17314-6 - MAG IgM Ser IA-aCnc
- 49275-1 - Interpretation SerPl IFE-Imp
- 61177-2 - Paraneoplastic Ab Ser Ql IF
- 33358-3 - M Protein SerPl Elph-mCnc
- 11502-2 - Laboratory report
Result Turnaround Time
3-9 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
5 mL
Minimum Volume
2.5 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection. Transfer serum to an ARUP standard transport tube.
Storage Instructions
Refrigerated
Causes for Rejection
Plasma, CSF, or other body fluids. Contaminated, heat-inactivated, grossly hemolyzed, severely icteric, or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | 1 week |
| Frozen | 1 month |
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