Motor and Sensory Neuropathy Evaluation with Reflex to Titer and Neuronal Immunoblot
Also known as: MSNER
Use
This test aids in the diagnosis of a combined motor/sensory neuropathy when a malignancy other than plasma cell dyscrasia is suspected. It is useful in differentiating between various peripheral neuropathies by identifying specific autoantibodies that are associated with these conditions.
Special Instructions
Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. Additional charges apply.
Limitations
This test has not been cleared or approved by the U.S. Food and Drug Administration but is performed in a CLIA certified laboratory intended for clinical purposes. The test by itself is not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 88723-2
- 31500-2
- 88724-0
- 88730-7
- 88729-9
- 31666-1
- 17314-6
- 61177-2
Result Turnaround Time
1-9 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
1 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection.
Causes for Rejection
Plasma, CSF, or other body fluids. Contaminated, heat-inactivated, hemolyzed, severely icteric, or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year |