Multiple Myeloma Panel by FISH
Also known as: FISHMMP
Use
This test is used for risk stratification of individuals with plasma cell neoplasms such as monoclonal gammopathy of unknown significance (MGUS), smoldering multiple myeloma (SMM), and multiple myeloma (MM). It aids in the initial diagnosis and/or monitoring during disease progression. The test analyzes CD138+ enriched cells for multiple myeloma prognosis-specific genomic abnormalities, including deletions, amplifications, and fusion patterns relevant to the disease's progression and prognosis.
Special Instructions
Not provided.
Limitations
If the enrichment process fails to yield sufficient CD138+ cells, testing will be performed using unenriched cells if available. Specimen integrity and sufficient cellularity are crucial for the completion of various aspects of the panel, including microarray and karyotype, which may be given lower priority than FISH in low cellularity samples. A processing fee applies if the procedure is cancelled after setup or if specimen integrity is inadequate.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 57802-1 - Chrom analy interphase Bld/Mar FISH-Imp
Result Turnaround Time
5-12 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
3 mL
Minimum Volume
1 mL
Container
green (sodium heparin) tube
Collection Instructions
Collect nondiluted bone marrow in a heparinized syringe.
Storage Instructions
Room temperature.
Causes for Rejection
Frozen specimens. Paraffin-embedded specimens. Clotted specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 48 hours |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant