Multiple Myeloma Panel by FISH

Casandra

Casandra Test Code AR72198Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 3002063CPT Codes 88271, 88275

Multiple Myeloma Panel by FISH

Also known as: FISHMMP

Clinical Use

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Use

This test is used for risk stratification of individuals with plasma cell neoplasms such as monoclonal gammopathy of unknown significance (MGUS), smoldering multiple myeloma (SMM), and multiple myeloma (MM). It aids in the initial diagnosis and/or monitoring during disease progression. The test analyzes CD138+ enriched cells for multiple myeloma prognosis-specific genomic abnormalities, including deletions, amplifications, and fusion patterns relevant to the disease's progression and prognosis.

Special Instructions

The test must be ordered with Oncology test request form #43099 or through the ARUP interface. Additional specimens may be required if concurrent testing such as chromosome analysis or genomic microarray is ordered, due to the need for CD138+ cell enrichment. Specimen collection and transportation instructions should be followed carefully.

Limitations

If the enrichment process fails to yield sufficient CD138+ cells, testing will be performed using unenriched cells if available. Specimen integrity and sufficient cellularity are crucial for the completion of various aspects of the panel, including microarray and karyotype, which may be given lower priority than FISH in low cellularity samples. A processing fee applies if the procedure is cancelled after setup or if specimen integrity is inadequate.

Test Details

New York Approved