Pancreatobiliary FISH
Also known as: PF REQUEST
Use
The Pancreatobiliary FISH test detects aneuploidy for chromosomes 3, 7, and 17 and is used in conjunction with standard diagnostic procedures as an aid for diagnosing pancreatic cancer. It helps in identifying numeric chromosomal aberrations associated with pancreatobiliary carcinoma, providing crucial information to guide further clinical evaluation and decision-making.
Special Instructions
This test requires specimen collection in a UroCyte Collection Kit, obtainable through ARUP Connect or Client Services. Specimen source must be provided, and the specimen should be placed in Cytolyt or PreservCyt fixative immediately after collection. Test results should be interpreted alongside clinical evidence and other laboratory tests.
Limitations
Negative results do not rule out pancreatobiliary carcinoma, especially in symptomatic patients, due to the possibility of false negatives. Positive results indicate chromosomal abnormalities but do not specify the malignancy's location or type. Additionally, some genetic changes associated with pancreatobiliary cancers might not be detectable by this test.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 66746-9
- 8100-0
- 22636-5
- 22634-0
Result Turnaround Time
4-14 days
Related Documents
For more information, please review the documents below
Specimen
Other
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Collect bile or pancreatic duct brushings, biliary stent, or fine needle aspirates of the pancreas. Place in Cytolyt or PreservCyt fixative vial immediately after collection. Submit the brush in the fixative if it's a brushing specimen.
Storage Instructions
Store at ambient or refrigerated temperatures.
Causes for Rejection
Frozen specimens and specimens not collected in Cytolyt or PreservCyt fixative.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week from collection |
| Refrigerated | 1 week from collection |
| Frozen | Unacceptable |