Parvovirus B 19 Antibody, IgM
Use
The test is used to detect IgM antibodies specific to Parvovirus B19, which may indicate a current or recent infection. The appearance of an IgM antibody response normally occurs 7 to 14 days after the onset of disease. It is recommended to conduct testing on two appropriately timed specimens simultaneously in the same laboratory to determine a significant change, providing the best evidence for current infection.
Special Instructions
This test is not recommended as a standalone test. It is suggested to use Parvovirus B19 Antibodies, IgG, and IgM (0065120) for better evaluation. Parallel testing with convalescent specimens, which must be received within 30 days from the receipt of the acute specimens, is preferred. Mark specimens as 'acute' or 'convalescent' clearly.
Limitations
The test results need to be interpreted cautiously as low levels of IgM antibodies may occasionally persist for more than 12 months post-infection. Testing immediately post-exposure is of no value without a subsequent convalescent specimen. For accurate diagnosis, changes in IgM antibody levels should be checked in sera from patients three to four weeks later to differentiate between early and residual IgM responses.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 5274-6
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
Serum separator tube (SST)
Collection Instructions
Separate from cells ASAP or within 2 hours of collection.
Storage Instructions
Refrigerated.
Causes for Rejection
Bacterially contaminated, heat-inactivated, hemolyzed, icteric, lipemic, or turbid specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year (avoid repeated freeze/thaw cycles) |