Primary Biliary Cholangitis Panel
Also known as: BILIARY CH
Use
This panel is the recommended autoantibody panel for evaluating individuals with suspected primary biliary cholangitis (PBC). The presence of specific antibodies such as Mitochondrial (M2) Antibody, Anti-gp210 Antibody, and Anti-sp100 Antibody can aid in the diagnosis of PBC. These antibodies are significant as they can be detected in patients, helping in the diagnostic process despite the variability in antibody presence between different patients or assays.
Special Instructions
Serum separator tubes (SST) should be used for collection, and serum must be separated from cells as soon as possible or within 2 hours of collection. The sample should be refrigerated for transportation.
Limitations
While anti-mitochondrial antibodies (AMA) are thought to be present in 90-95% of PBC patients, the frequency of detectable antibodies can vary. Not all PBC patients test positive for AMA. Some may be positive for SP100 and/or GP210 antibodies, which have lower sensitivity but excellent specificity. Negative results do not rule out PBC, necessitating further serologic testing.
New York Approved
Methodology
Immunoassay
Biomarkers
LOINC Codes
- 14251-3
- 21424-7
- 49311-4
- 96560-8
- 96565-7
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1.2 mL
Minimum Volume
0.8 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate from cells ASAP or within 2 hours of collection.
Storage Instructions
Refrigerated.
Causes for Rejection
Non-serum, heat-inactivated, contaminated, grossly icteric, severely lipemic, grossly hemolyzed specimens, or inclusion of fibrin clot.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month |