Streptolysin O Antibody (ASO)
Also known as: ASO
Use
The Streptolysin O Antibody (ASO) test is used to confirm a prior infection with group A Streptococcus in patients suspected of having a nonsuppurative complication such as acute glomerulonephritis (AGN) or acute rheumatic fever (ARF). Elevated titers of antideoxyribonuclease B antibody (anti-DNase B) or antistreptolysin O antibody (ASO) indicate a recent group A Streptococcus infection. Anti-DNase B antibodies typically remain elevated longer than ASO and may remain elevated for several months after infection. Patients with normal ASO but elevated anti-DNase B could have complications related to recent Streptococcus infection.
Special Instructions
Tests such as DNase-B Antibody (0050220) and Streptolysin O Antibody (ASO) (0050095) are generally ordered concurrently for better diagnosis accuracy. Ensure proper serum separation and specimen management according to the guidelines provided.
Limitations
Patients suspected of having complications related to a recent Streptococcus infection may have elevated anti-DNase B but normal ASO antibody titers. A negative or very low anti-DNase B and ASO antibody titers, especially from a specimen tested 2 weeks after a suspected infection, indicates an unlikely incidence of a recent Streptococcus infection. These limitations must be considered when interpreting test results.
FDA ApprovedNew York Approved
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
LOINC Codes
- 5370-2
- 5370-2
Result Turnaround Time
0-1 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.4 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection. Transfer to an appropriate container.
Storage Instructions
Refrigerated.
Causes for Rejection
Hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 8 hours |
| Refrigerated | 8 days |
| Frozen | 3 months |