Antistreptolysin O (ASO) Antibodies
Use
The test is used to document exposure to streptococcal streptolysin O. A significant rise in the ASO titer or a persistently elevated titer indicates a current or past infection with Streptococcus, or poststreptococcal sequelae. ASO levels help in diagnosing and managing diseases caused by Group A Streptococcus infections, particularly rheumatic fever and glomerulonephritis.
Special Instructions
Not provided.
Limitations
False-positive results can occur due to elevated serum β-lipoprotein levels seen in liver disease, or contamination of the serum with Bacillus cereus and Pseudomonas species. Although ASO titers are elevated in about 85% of rheumatic fever patients, they may not be elevated in cases involving skin or renal sequelae. For such conditions, the anti-DNase B test may be a more suitable option. It is important to correlate ASO titer results with clinical presentations and other diagnostic procedures.
Methodology
Immunoassay (Other)
Biomarkers
Antistreptolysin O Antibody
Analyte
LOINC Codes
- 5370-2
- 5370-2
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Causes for Rejection
Gross hemolysis; lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
Other tests from different labs that may be relevant