Streptolysin O Antibody (ASO)
Also known as: ASO
Use
The Streptolysin O Antibody (ASO) test is used to confirm a prior infection with group A Streptococcus in patients suspected of having a nonsuppurative complication such as acute glomerulonephritis (AGN) or acute rheumatic fever (ARF). Elevated titers of antideoxyribonuclease B antibody (anti-DNase B) or antistreptolysin O antibody (ASO) indicate a recent group A Streptococcus infection. Anti-DNase B antibodies typically remain elevated longer than ASO and may remain elevated for several months after infection. Patients with normal ASO but elevated anti-DNase B could have complications related to recent Streptococcus infection.
Special Instructions
Not provided.
Limitations
Patients suspected of having complications related to a recent Streptococcus infection may have elevated anti-DNase B but normal ASO antibody titers. A negative or very low anti-DNase B and ASO antibody titers, especially from a specimen tested 2 weeks after a suspected infection, indicates an unlikely incidence of a recent Streptococcus infection. These limitations must be considered when interpreting test results.
FDA ApprovedNew York Approved
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
Streptolysin O
Protein
LOINC Codes
- 5370-2
- 5370-2
Result Turnaround Time
0-1 day
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.4 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection. Transfer to an appropriate container.
Storage Instructions
Refrigerated.
Causes for Rejection
Hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 8 hours |
| Refrigerated | 8 days |
| Frozen | 3 months |
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