T-Cell Clonality Screening by PCR
Also known as: T CELL-F
Use
This test aids in the diagnosis of T-cell lymphoproliferative disorders by detecting monoclonal T-cell receptor gamma gene rearrangements. Monoclonal rearrangements are indicative of a clonal T-cell population, which may suggest the presence of T-cell lymphoproliferative disease although it does not necessarily indicate malignancy. This test is particularly useful in distinguishing between reactive and neoplastic T-cell proliferations.
Special Instructions
Not provided.
Limitations
The presence of a clonal T-cell population does not imply malignancy without considering morphologic, clinical, and other relevant data. The test is not designed to detect minimal residual disease and cannot detect clonal populations beyond its limits or unamplified by the PCR primers. It has a detection limit of 12.5 percent monoclonal T cells within total T cells.
New York Approved
Methodology
PCR-based
Biomarkers
No genes
Gene
LOINC Codes
- 21753-9 - TCRG gene Rear Bld/T Ql
- 66746-9 - Specimen type
Result Turnaround Time
5-9 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
1 mL
Container
lavender (EDTA)
Storage Instructions
Refrigerated
Causes for Rejection
Plasma, serum. Clotted or grossly hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | 7 days |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant