T-Cell Clonality Screening by PCR

Casandra

Casandra Test Code AR19619Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0055567CPT Code 81342

T-Cell Clonality Screening by PCR

Also known as: T CELL-F

Clinical Use

Order Test

Use

This test aids in the diagnosis of T-cell lymphoproliferative disorders by detecting monoclonal T-cell receptor gamma gene rearrangements. Monoclonal rearrangements are indicative of a clonal T-cell population, which may suggest the presence of T-cell lymphoproliferative disease although it does not necessarily indicate malignancy. This test is particularly useful in distinguishing between reactive and neoplastic T-cell proliferations.

Special Instructions

If submitting multiple specimens, they must include a comment for pathologist selection or individual orders. A Pathologist Block Selection Fee will apply when ARUP pathologist chooses the specimen. Ensure that FFPE specimens are fixed in 10 percent neutral buffered formalin.

Limitations

The presence of a clonal T-cell population does not imply malignancy without considering morphologic, clinical, and other relevant data. The test is not designed to detect minimal residual disease and cannot detect clonal populations beyond its limits or unamplified by the PCR primers. It has a detection limit of 12.5 percent monoclonal T cells within total T cells.

Test Details

New York Approved