Thyroid Peroxidase (TPO) Antibody
Also known as: AMICR
Use
The Thyroid Peroxidase (TPO) Antibody test is used to distinguish between autoimmune and non-autoimmune thyroid disorders, such as hypothyroidism, by measuring antibodies against thyroid peroxidase in the blood. Autoimmune thyroid disorders are often associated with an increased risk of developing other autoimmune diseases, thus timely and accurate diagnosis is crucial for the management of these conditions. It is commonly used to aid in diagnosing Hashimoto's thyroiditis and other forms of autoimmune thyroiditis, especially in pregnant women, as thyroid function can significantly impact pregnancy outcomes.
Special Instructions
Not recommended for initial testing of thyroid disorders. It is important to use this test to differentiate between autoimmune thyroid conditions like Hashimoto's thyroiditis and other forms of thyroid disorders. Proper interpretation of results in the context of clinical findings is essential for a correct diagnosis.
Limitations
The test should not be used as the initial screening for thyroid dysfunction. False negatives can occur, especially in the early stages of disease or after treatment has begun. Additionally, false positives may be found in the setting of other autoimmune conditions. Interfering substances in the blood sample, such as lipemia or hemolysis, can affect the accuracy of the test results.
FDA ApprovedNew York Approved
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 8099-4
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
ARUP standard transport tube
Collection Instructions
Transfer 0.5 mL serum or plasma to an ARUP standard transport tube. Also acceptable: Lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin).
Storage Instructions
Refrigerated
Causes for Rejection
Grossly hemolyzed or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 8 hours |
| Refrigerated | 1 week |
| Frozen | 6 months |