Trazodone, Serum/Plasma

Casandra

Casandra Test Code AR81386Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 3005860CPT Codes 0480, 80338

Trazodone, Serum/Plasma

Also known as: TRAZO SP

Clinical Use

Order Test

Use

Trazodone is a selective serotonin reuptake inhibitor antidepressant drug indicated for the treatment of major depressive disorder. The pharmacokinetics of trazodone is influenced by drug-drug interactions that induce or inhibit CYP3A4 metabolism. Therapeutic drug monitoring is used to optimize drug therapy and monitor patient adherence. The test helps in managing adverse effects such as sedation, fatigue, headache, blurred vision, nausea, and cardiac arrhythmia, and addresses risks of serotonin syndrome when used with other serotonergic drugs.

Special Instructions

Specimen should be collected as a pre-dose (trough) draw at steady state concentration for optimal results. Refrigerated transport of specimens is preferred to ensure stability. Whole blood and gel separator tubes are not acceptable.

Limitations

The toxic range for trazodone is not well established, which may limit the ability to determine overdose levels through this test. The test has not been cleared or approved by the U.S. Food and Drug Administration and is developed by ARUP Laboratories as a Laboratory Developed Test (LDT) for use in a CLIA-certified facility. Drug-drug interactions affecting CYP3A4 metabolism can alter test results.

Test Details

New York Approved