Zinc Protoporphyrin (ZPP), Whole Blood
Also known as: ZPP
Use
Zinc Protoporphyrin (ZPP) is useful for evaluating the body's iron status and detecting lead exposure. Elevated levels of ZPP are commonly found in cases of early and late iron deficiency, anemia of chronic disease, and chronic lead poisoning. It is also an indication of erythropoietic protoporphyria. However, this test should not be used as a primary screening tool for lead exposure, for which Lead Blood (Venous) is preferred. It also should not replace tests for assessing iron deficiency such as Iron and Iron Binding Capacity or Ferritin. Occupational exposure assessment to lead is better evaluated with the Lead Industrial Exposure Panel, Adults.
Special Instructions
Samples should be transported as whole blood in the original collection tubes. Recommended patient preparation includes the use of Lavender (EDTA), royal blue (K2EDTA), royal blue (NaHep), tan (K2EDTA), or pink (K2EDTA) tubes.
Limitations
The test result may be falsely elevated by the presence of elevated bilirubin, riboflavin, or if the specimen is hemolyzed, clotted, or improperly aliquoted. It is important to note that the ZPP results from this test are not comparable to results obtained from extraction-based methods or from the AVIV ZPP system. This limitation should be considered when interpreting results alongside other methodologies.
New York Approved
Methodology
Automated Analyzer (Hematology)
Biomarkers
LOINC Codes
- 29763-0
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
3 or 6 mL
Minimum Volume
0.2 mL
Container
Lavender (EDTA), royal blue (K2EDTA), royal blue (NaHep), tan (K2EDTA), or pink (K2EDTA)
Storage Instructions
Refrigerated
Causes for Rejection
Clotted, frozen, or hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 30 hours |
| Refrigerated | 5 weeks |