Carnitine Determination - Plasma
Use
This test provides a quantitative analysis of free carnitine, acylcarnitine, and total carnitine in plasma. Carnitine and its derivatives are essential for normal energy metabolism. The evaluation of carnitine levels aids in identifying patients with carnitine cycle disorders, as well as abnormal levels due to organic acidemias and fatty acid oxidation disorders. Monitoring carnitine is particularly crucial in patients with certain kidney and seizure disorders. It is indicated for those with clinical suspicion of relevant metabolic conditions or a history of symptoms like feeding abnormalities, failure to thrive, seizures, or hepatomegaly.
Special Instructions
The test requires blood to be drawn in a Sodium Heparin tube, which should be separated promptly. A minimum of 1-2 cc of plasma is needed for analysis. The specimen must be stored frozen at -20°C and shipped on dry ice. Should you require further information about kits or resources, please reference the provided links for ordering and patient resources.
Limitations
Factors such as improper specimen collection, separation delays, and inadequate storage conditions may affect test results. Additionally, variations in metabolism and other underlying conditions may influence carnitine levels and should be interpreted within the context of the clinical picture. Ensure that the specimen is processed and sent according to specified guidelines to minimize these risks.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
Result Turnaround Time
8 days
Related Documents
For more information, please review the documents below
Specimen
Plasma (Frozen)
Volume
1-2 cc
Minimum Volume
1 cc
Container
Sodium Heparin (green-top) tube
Collection Instructions
Draw blood in a Sodium Heparin tube and separate as soon as possible.
Storage Instructions
Store the specimen frozen at -20C.
Causes for Rejection
Specimens not stored properly or collected in incorrect tubes may be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | Up to 7 days |