Xpanded® Adult Movement Disorders Panel
Use
The Xpanded® Adult Movement Disorders Panel is a phenotype‑driven, comprehensive genetic test that employs whole‑exome capture and next‑generation sequencing with analysis targeted to a curated list of approximately 500 genes associated with adult‑onset movement disorders. It aids in identifying pathogenic and likely pathogenic variants relevant to diagnostic decision‑making. Variants of uncertain significance are generally not reported unless deemed appropriate, and benign/likely benign variants are excluded. Additionally, incidental findings with potential clinical impact (e.g., cancer, cardiac or metabolic risk genes) are disclosed to the ordering provider when identified.
Special Instructions
Analysis is phenotype‑driven using a gene list curated from OMIM, HGMD, and HPO terms, regularly reviewed with additions or removals based on GeneDx clinical exome sequencing data in adult‑onset movement disorder cases. A variant list file is available on request. Trio (proband and family members) testing is preferred.
Limitations
Although the panel includes ~500 genes, it does not provide a comprehensive list of all observed variants; the report may not list all findings. Variants of uncertain significance are not routinely reported. Incidental findings may arise outside the indication and will be disclosed when likely to impact care.
Methodology
NGS (CGP)
Biomarkers
Result Turnaround Time
28 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
Not provided
Minimum Volume
Not provided