Invitae Dilated Cardiomyopathy and Left Ventricular Noncompaction Panel
Use
The Invitae Dilated Cardiomyopathy and Left Ventricular Noncompaction Panel includes genes associated with dilated cardiomyopathy (DCM) and left ventricular noncompaction (LVNC). These conditions can cause symptoms such as chest pain, heart failure, arrhythmia, or stroke. The panel aids in diagnosing these conditions and assessing asymptomatic individuals with a known familial variant. Syndromic conditions that mimic DCM or LVNC are also evaluated, helping to identify potential multi-system disorders presenting with left ventricular dilation.
Special Instructions
The test analyzes clinically important gene regions, including coding exons and select intronic sequences. Variants outside these regions are not analyzed. Results are based on extracted genomic DNA and might not represent the patient's constitutional genome in rare cases, such as recent blood transfusions.
Limitations
The test shows >99% sensitivity and specificity for variants less than 15bp and exon-level changes. Variants like structural rearrangements or complex embedded sequences may not be detected. Some single-exon events might not be analyzed due to sequence properties. Changes in non-coding regions like promoters are not covered unless specified.
New York Approved
Methodology
NGS (Targeted)
Biomarkers
Result Turnaround Time
10-21 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
3mL
Minimum Volume
Not provided
Container
purple-top EDTA tube (K2EDTA or K3EDTA)