17-OH Progesterone/Creatinine Ratio, Random Urine
Also known as: 17-OHP Urine
Use
17-Hydroxyprogesterone (17-OHP) in urine is greatly elevated in patients with polycystic ovarian disease and in patients with idiopathic hirsutism. Wong and coworkers showed that measurement of 17-OHP in 24-hour urine produced results that may be useful for monitoring glucocorticoid and mineralocorticoid therapy in patients with congenital adrenal hyperplasia (CAH).1 Other studies have shown that 17-OHP in 24-hour urine correlated well with serum 17-OHP and suggested that the urine measurement of 17-OHP may be a reliable alternative to serum 17-OHP measurement for monitoring of CAH therapy.2,3
Special Instructions
Random urine collection is required. If the original container is received with pH >3 but <5, adjust the pH to <3 using 6N HCl to ensure accurate test results.
Limitations
This test has been developed and its performance characteristics determined by Labcorp. However, it has not been cleared or approved by the Food and Drug Administration, which limits its use to settings that understand and accommodate for the lack of such clearance or approval. The validity of the test is supported by published research, but users should be cautious about interpretative constraints in broader clinical contexts.
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 1670-9
- 2161-8
- 63042-6
- 1670-9
- 2161-8
- 63042-6
Result Turnaround Time
4-6 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
30 mL aliquot
Minimum Volume
4 mL aliquot
Container
Random urine transport tube containing 6N HCl or urine Monovette® with pH stabilizer
Collection Instructions
Ensure to add preservative to the container prior to collection. Use plastic urine container if collecting without Monovette®, adjusting pH to <5 with 6N HCl.
Storage Instructions
Refrigerate the specimen.
Causes for Rejection
Specimen with no preservative; original container with pH >5
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 14 days |