β2-Glycoprotein 1 Antibodies, IgA, IgG, IgM

Casandra

Casandra Test Code LC67245Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 163915CPT Code 86146

β2-Glycoprotein 1 Antibodies, IgA, IgG, IgM

Also known as: Anti-β2 Glycoprotein 1, Beta-2 Glycoprotein 1 Antibodies, IgG, IgA, IgM

Clinical Use

Order Test

Use

Assess the risk of thrombosis in patients who may be at risk for antiphospholipid syndrome (APS). This test should be used in conjunction with current traditional anticardiolipin and anticoagulant tests.1

Special Instructions

The test findings should not be used in isolation to diagnose antiphospholipid syndrome; it should always be used in conjunction with other diagnostic criteria and traditional testing methods such as anticardiolipin and anticoagulant tests.

Limitations

Anti-β2-glycoprotein 1 antibodies should not be employed alone as a screening tool for APS. Approximately 30% of patients might show discordant results between anticardiolipin antibodies and β2-Glycoprotein 1 antibodies. About 20% of patients who test negative for anticardiolipin antibodies will test positive for β2-GP1. Moreover, anti-β2-GP1 response might not support an APS diagnosis if it concomitantly shows negative lupus anticoagulant and anticardiolipin outcomes.

Test Details