β2-Glycoprotein 1 Antibodies, IgG, IgM

Casandra

Casandra Test Code LC39787Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 163002CPT Code 86146

β2-Glycoprotein 1 Antibodies, IgG, IgM

Also known as: Anti-β2 Glycoprotein 1, Beta-2 Glycoprotein 1 Antibodies

Clinical Use

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Use

Assess the risk of thrombosis in patients who may be at risk for antiphospholipid syndrome (APS). This test should be used in conjunction with current traditional anticardiolipin and anticoagulant tests.1

Special Instructions

Recently, an international consensus group of experts in the diagnosis and management of antiphospholipid syndrome concluded that β2-Glycoprotein 1 IgG and IgM antibodies should be included as diagnostic criteria for APS. The test includes semiquantitative results for IgG and IgM antibodies against β2-glycoproteins.

Limitations

Anti-β2-glycoprotein 1 should not be used alone as a screening test for antiphospholipid syndrome. Testing positive for β2-GP1 antibodies can occur in approximately 20% of patients who test negative for anticardiolipin antibodies (ACA). This test is useful in patients with positive ACA results and a clinical picture inconsistent with APS. However, a negative anti-β2-GP1 result does not exclude APS if clinical suspicion is strong.

Test Details