Allergen Profile With Component Reflexes, Respiratory–Area 12
Use
Detect possible allergic responses to various substances in the environment (see Test Includes) and evaluate for hay fever, asthma, atopic eczema, and respiratory allergy. The quantitative allergen-specific IgE test is indicated (1) to determine whether an individual has elevated allergen-specific IgE antibodies; (2) if specific allergic sensitivity is needed to allow immunotherapy to be initiated; (3) when testing individuals for agents that may potentially cause anaphylaxis; (4) when evaluating individuals who are taking medication (eg, long-acting antihistamines) that may interfere with other testing modalities (eg, skin testing); (5) if immunotherapy or other therapeutic measures based on skin testing results have not led to a satisfactory remission of symptoms; (6) when an individual is unresponsive to medical management where identification of offending allergens may be beneficial.
Special Instructions
The test requires a serum sample and is carried out using Thermo Fisher ImmunoCAP® methodology. Reflex testing for cat and dog components is performed if specific IgE levels are ≥0.35 kU/L, allowing for further detailed allergen analysis. Turnaround time for results is typically between 3 to 5 days, dependent on the pickup date of the specimen.
Limitations
The interpretation of allergen-specific IgE results should be combined with a detailed clinical history to ascertain their significance. This test may not cover all possible allergen sensitivities, and cross-reactivity can occur among allergens, which may affect specificity. Reflex testing is dependent on the initial IgE measurement triggering further tests for detailed component analysis. Delays can occur if additional confirmatory tests are required.
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 96185-4
- 8251-1
- 19113-0
- 6096-2
- 6095-4
- 6833-8
- 6098-8
- 6041-8
- 7369-2
- 6152-3
- 6078-0
- 6212-5
- 6075-6
- 6025-1
- 6020-2
- 6192-9
- 6178-8
- 6189-5
- 6109-3
- 6090-5
- 6015-2
- 6085-5
- 6183-8
- 6234-9
- 7604-2
- 6181-2
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3.5 mL
Minimum Volume
Not provided
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Causes for Rejection
Inadequate labeling; gross hemolysis
